Blumenthal M, Brinckmann J, Wollschlaeger B. St. John's Wort: Clinical Overview. Perhaps the most well-known effect of St. Johns wort is its anti-depressant nature. The true benefits of St. John's wort are still being explored. Ornamental Use. St John's wort is a herbal remedy most often used to treat depression. Famously known for easing depression, anxiety, SAD, and OCD, St. John’s Wort is also an exceptional anti-inflammatory and antimicrobial. By the end of the eight-week trial, the average daily dose was 1,300mg per day. Advertising on our site helps support our mission. You should not take St. John's wort for two weeks before having surgery. If you have received an organ transplant, you will need to avoid St. John's wort as it can interact with the medications given to help prevent transplant rejection. In 2007, the National Health Interview Survey found a large decrease in St. John's wort use by adults in the United States, when it was not among the 20 most commonly used dietary supplements . One reason people may wish to try the natural remedy for depression (as opposed to antidepressants that can increase serotonin) is that St. John's wort tends to have fewer side effects than medications. The herb is also being explored for the following health concerns: An oil made from St. John’s wort has also been used topically for wound healing and a variety of other skin conditions such as eczema and hemorrhoids. The plant is used in herbal medicine as a treatment for depression, and there is some limited clinical evidence of its efficacy. 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But because St. John's wort causes many drug interactions it might not be an appropriate choice, particularly if you take any prescription drugs. Continuing Education in Anaesthesia Critical Care & Pain. Greek and Roman medical sources report the use of St. John's wort as a topical treatment for healing wounds and for treating kidney stones, sciatica, menstrual problems and snakebites. St. John's wort is widely available in pharmacies, supermarkets, and health food stores and comes in different doses. A systematic review of St. John’s wort for major depressive disorder. Does St. John's Wort Have Any Drug Interactions With Antidepressants? Delaying or forgoing treatment for depression can have serious consequences. For example, if you are pregnant, breastfeeding, trying to conceive, or taking oral contraceptives (birth control pills), it's important to talk with your doctor before you start taking St. John's wort. As you are deciding on treatment, remember to tell each health care provider you work with about all the medications you are taking, including herbal or nutritional supplements, to ensure no potentially dangerous interactions occur. Study results on the effectiveness of Hypericum perforatum for depression have been mixed. Melt in a double boiler or small crock pot on low until beeswax is dissolved. This condition is known as serotonin syndrome. Always tell your doctor or pharmacist if you are taking St. John's wort or any other herbal product. National Center for Complementary and Integrative Health. St. John's wort (Hypericum perforatum) is an herbal compound used in the treatment of burns, bruises, swelling, anxiety, and most recently, mild to moderate depression. You should avoid taking any nutritional supplement or remedy that can raise serotonin, such as 5-hydroxytryptophan (5-HTP), L-tryptophan, or SAMe if you are taking St. John's wort. In: The ABC Clinical Guide to Herbs. St. John's wort has been used in alternative medicine as a possibly effective aid in treating somatization disorder (physical illness or symptoms without a known cause), or hot flashes caused by menopause. Unlike prescription and over-the-counter drugs, herbal supplements don't always come in child-proof containers. St John’s wort. One of the most well-known species is the common, or perforated, Saint-John’s-wort (H. perforatum), which is native to Europe, northern Africa, and western Asia. St. John’s wort (both oral or topical) can also increase the sensitivity of your skin and eyes to sunlight. Questions and Answers: A Trial of St. John's Wort (Hypericum perforatum) for the Treatment of Major Depression. Today it is mainly used as an over-the-counter remedy to treat mild and moderate depression , and sometimes seasonal affective disorder (SAD) , mild anxiety and sleep problems . St. John's wort has several traditional uses. The genus Hypericum (which is variously assigned to the families Hypericaceae , Guttiferae , or Clusiaceae ) contains some 300 species of plants ranging from creeping forms to 15-foot-tall shrubs. In NIH-funded trials, participants were given a 300mg dose of a specific concentration of St. John's wort extract three times a day (900mg daily total).