Commonly reported side effects of doxorubicin include: severe nausea and vomiting, nausea and vomiting, and alopecia. Along with its needed effects, doxorubicin may cause some unwanted effects. Doxorubicin side effects vary between patients and range from minor to severe. Cough or hoarseness accompanied by fever or chills, darkening or redness of the skin (if you recently had radiation treatment), lower back or side pain accompanied by fever or chills, painful or difficult urination accompanied by fever or chills. Adriamycin PFS (doxorubicin)." This means that there is a maximum amount of doxorubicin a patient can take during its lifetime before its … The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500–550 mg/m , 18% when the dose is 551–600 mg/m and 36% when the dose exceeds 600 mg/m . Common side effects of Adriamycin PFS (doxorubicin hydrochloride) include: Information about indications was extracted from the indications and usage sections of the labels. Nausea and vomiting can be severe. Changes in diet and lifestyle, such as eating several small meals and limiting activity, may help lessen some of … Extravasation, or leaking of a drug outside of a vein, of some chemotherapeutics can cause mild to moderate tissue irritation, but doxorubicin can cause tissue sloughing, necrosis, and wounds that can take months to heal and may require amputation. Its cytotoxic effect produced by intercalating with DNA causing breakdown of DNA strand which causes cancer cell apoptosis. In some cases, drug therapy may be needed to prevent or relieve nausea and vomiting. Doxorubicin Side Effects What should I watch for? O 0. side pain. This drug may make you feel generally unwell. ... For example, your side effects could be worse if you're also having other drugs or radiotherapy. Doxorubicin (Intravenous Route) Print. lower back pain. You may report them to the FDA. Doxorubicin (DOX), the first-line chemotherapy for bladder cancer, usually induces side effects. swelling in the feet and legs. Doxorubicin Side Effects Video. 1. Some side effects may not be reported. Assess left ventricular ejection fraction (LVEF) before and regularly during and after treatment with DOXOrubicin hydrochloride. Your doctor, nurse or pharmacist will go through the possible side effects. … They will monitor you closely … This study aimed to investigate the additive/synergistic effect EGCG and DOX against bladder cancer. All rights reserved. Despite being an effective anticancer agent it causes several crucial side effects like carditoxicity, neuropathy, hepatotoxicity, nephrotoxicity, alopecia, typhlitis, myelosuppression, … Tests . Immediately terminate the drug, and apply ice to the affected area. Doxorubicin Liposome (Intravenous Route) Print. Description: Doxorubicin is a cytotoxic anthracycline antibiotic. bevacizumab. Doxorubicin causes various side effects, both short-term and long-lasting 1. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. We comply with the HONcode standard for trustworthy health information -. Along with its needed effects, a medicine may cause some unwanted effects. "Product Information. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088). This site complies with the HONcode standard for trustworthy health information: verify here. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Therefore, there is a lifetime maximum on the amount of doxorubicin you can receive. The early damage occurs immediately after drug administration or within 1 to 2 days. Doxorubicin, also called Adriamycin ®, is a chemotherapy drug used to treat many different types of cancer.. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. drug side effect resource. During this period of time, check with your doctor immediately if you notice the following side effects: Other side effects not listed may also occur in some patients. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Because doxorubicin attacks rapidly dividing cells it is also toxic to normal cells with high division rates: hair follicle cells, bone marrow cells, and intestinal cells. Call your doctor if you have any unusual problems while taking this medication. This is one of the main reasons that only trained personnel should handle doxorubicin. 2006). Sections. The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500-550 mg/m², 18% when the dose is 551-600 mg/m² and 36% when the dose exceeds 600 mg/m². It should be used under the supervision of a qualified physician. This is called intravesical chemotherapy and the side effects are different to doxorubicin given into a vein. Doxorubicin Hcl Side Effects See also Warning section. Check with your doctor or nurse immediately if any of the following side effects occur while taking doxorubicin: Some side effects of doxorubicin may occur that usually do not need medical attention. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. How does AC (Adriamycin and Cytoxan [cyclophosphamide]) work for Breast Cancer? Doxorubicin may cause other side effects. Peripheral neurotoxicity has never been reported as a clinically relevant problem in doxorubicin administration. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Last updated on Oct 30, 2020. Mayo Clinic does not endorse companies or products. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, Cough or hoarseness accompanied by fever or chills, darkening or redness of the skin (if you recently had radiation treatment), lower back or side pain accompanied by fever or chills, painful or difficult urination accompanied by fever or chills. Veterinary technicians who handle doxorubicin must understand the emergency procedures necessary i… What are the long-term side effects of Adriamycin? They … All rights reserved. Doxorubicin may cause serious side effects including: Heart problems. These side effects may go away during treatment as your body adjusts to the medicine. You usually have this type of chemotherapy as a course of several cycles of treatment. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). The anthracycline doxorubicin (DOX) is widely used in chemotherapy due to its efficacy in fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers. fast or irregular heart beat. These problems can happen during your treatment or months to years after stopping treatment. This content does not have an English version. Indications. You have blood tests before and during your treatment. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Cerner Multum, Inc. "UK Summary of Product Characteristics." Medically reviewed by Drugs.com. It is best to read this information with our general information about chemotherapy and the type of cancer you have.. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. Find everything you need to know about Doxorubicin (Adriamycin), including what it is used for, warnings, reviews, side effects, and interactions. Severe myelosuppression resulting in serious infection, septic shock, requirement for transfusions, hospitalization, and death may occur. Know uses, side effects, dosage, contraindications, … While other anthracyclines (like epirubicin and mitoxantrone) may also cause heart damage, the chances are more common with doxorubicin. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Because clinical trials are conducted under very specific conditions, the adverse event ... pharmacological effects of doxorubicin doxorubicin metabolism increased by barbiturates via CYP3A4 induction : monitor therapy . Common side effects include lowered white and red blood cell counts, which increase your risk of infection and anemia; loss of appetite; hair loss; and nausea and vomiting. The most dangerous side effect of doxorubicin is dilated cardiomyopathy, leading to congestive heart failure. There are several ways in … This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Pharmacia and Upjohn, Kalamazoo, MI. Close monitoring of kidney function and blood cell count is necessary while receiving this medication. See below for a comprehensive list of adverse effects. SIDE EFFECTS. It is well recognized that doxorubicin may cause damage to the heart in some individuals. Copyright © 2021 IBM Watson Health. Your chance of heart problems is higher if you: already have heart problems; Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: After you stop using this medicine, it may still produce some side effects that need attention. Common side effects may include: nausea, vomiting; or hair loss. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Although not all of these side effects may occur, if they do occur they may need medical attention. prednisone, methotrexate, dexamethasone, Arimidex, Armour Thyroid, Keytruda, fluorouracil, rituximab, Ibrance, Imbruvica. 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During this period of time, Check with your doctor immediately if you notice the following side effects: Applies to doxorubicin: compounding powder, intravenous powder for injection, intravenous solution, Common (1% to 10%): Cardiomyopathy, decreased LVEF, ECG changes (e.g., sinus tachycardia, tachyarrhythmia, ventricular tachycardia, bradycardia, bundle branch block), congestive heart failure, Very rare (less than 0.01%): Pericarditis, myocarditis, Postmarketing reports: Cardiogenic shock, phlebosclerosis, phlebitis/thrombophlebitis, hot flashes, thromboembolism[Ref], Very common (10% or more): Leucopenia (60% to 80%), Common (1% to 10%): Bone marrow suppression, Uncommon (0.1% to 1%): Thrombocytopenia[Ref], Rare (less than 0.1%): Urticaria, exanthema, local erythematous reactions along the vein which was used for the injection, hyperpigmentation of skin and nails, onycholysis, Postmarketing reports: Oncolysis, rash, itching, photosensitivity, urticaria, acral erythema, palmar plantar erythrodysesthesia[Ref], Very common (10% or more): Nausea and vomiting (20% to 85%), stomatitis (up to 80%), diarrhea (12%), Uncommon (0.1% to 1%): Ulceration and necrosis of the colon, especially the cecum (in combination with cytarabine)[Ref], Frequency not reported: Extravasation, tissue necrosis[Ref], Rare (0.01% to 0.1%): Anaphylactic reactions[Ref], Rare (0.01% to 0.1%): Renal insufficiency[Ref], Postmarketing reports: Malaise, asthenia, fever, chills[Ref], Common (1% to 10%): Secondary malignancies[Ref], Postmarketing reports: Keratitis, lacrimation[Ref], Common (1% to 10%): Local reactions (chemical cystitis) may occur with intravesical treatment, Rare (less than 0.1%): Bladder contracture, Frequency not reported: Hyperuricemia, tumor lysis syndrome, Postmarketing reports: Increased alanine aminotransferase, increased aspartate aminotransferase[Ref], Frequency not reported: Bronchospasm, cough, epistaxis, pneumonia, nasopharyngitis, upper respiratory tract infection[Ref], Postmarketing reports: Peripheral sensory and motor neuropathy, seizures, coma[Ref]. See also Warning section.Nausea, vomiting, diarrhea, and loss of appetite may occur. This content does not have an Arabic version. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: After you stop using this medicine, it may still produce some side effects that need attention. Tell your doctor if any of these symptoms are severe or do not go away: nausea; vomiting; sores in the mouth and throat; loss of appetite (and weight loss) weight gain; stomach pain; diarrhea; increased thirst ; unusual tiredness or weakness; dizziness; hair loss; separation of fingernail or toenail from the nail bed; itchy, red, watery, or irritated eyes; It works by blocking an enzyme called topo isomerase 2 that cancer cells need in order to divide and grow. It is also toxic to muscle cells, particularly heart muscle cells. These side effects may go away during treatment as your body adjusts to the medicine. Secondary acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) occur at a higher incidence in patients treated with anthracyclines, including DOXOrubicin hydrochloride. Doxorubicin Side Effects Common side effects of this medication include: Low white blood cell count (Leukopenia) Low platelet count (thrombocytopenia) Doxorubicin(Adriamycin PFS) generic is a cytotoxic anthracycline antibiotic, prescribed for treating various types of cancer. Body aches/pains, headache, nausea, vomiting, constipation, diarrhea, stomach upset, and loss of appetite may occur. Doxorubicin tissue extravasation has the potential to be catastrophic. 21. doxorubicin … However, its therapeutic value has been hampered by its severe dose-dependent cardiotoxic side effects, including dilated cardiomyopathy and congestive heart failure (Elliott 2006; Ng et al. The number of cycles you have depends on your treatment plan. Doxorubicin may cause side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Nausea, vomiting, diarrhea, and loss of appetite may occur. Call your doctor for medical advice about side effects. When to contact your team. Common severe doxorubicin side effects that should be immediately reported to a healthcare provider include (12): fever or chills (can be combined with hoarseness or cough) shortness of breath. The most dangerous side effect of doxorubicin is dilated cardiomyopathy, leading to congestive heart failure. stomach pain. In some cases heart problems are irreversible. 2. Our results demonstrated that the combined use of DOX and EGCG … Side Effects What are the side effects of Doxil (Doxorubicin Liposomal)?. Applies to doxorubicin: intravenous powder for solution, intravenous solution, Intravenous route (Solution; Powder for Solution). Nausea and vomiting can be severe. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In some cases, drug therapy may be needed to prevent or relieve nausea and vomiting. Side effects. We previously demonstrated that green tea polyphenol EGCG had potent anti-tumor effect in bladder cancer via down regulation of NF-κB. Drug information provided by: IBM Micromedex. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. If you notice any other effects, check with your healthcare professional. Other side effects of doxorubicin include: Sensitivity to sunlight (photosensitivity) Cardiac dysrhythmia; Necrotizing colitis; Myelosuppression; Hyperuricemia; Red urine; Hyperpigmentation of previously radiated areas ; This document does not contain all possible side effects and others may occur. 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A cytotoxic anthracycline antibiotic extracted from the indications and usage sections of the anthracycline family this study aimed to the... Way to lookup drug information, identify pills, check interactions and set up your own personal medication.! Treatment and its possible side effects, doxorubicin may cause some unwanted effects with concomitant cardiotoxic.! Identify pills, check with your healthcare provider to ensure the information displayed on page...